Seabasing and joint expeditionary logistics

Student Integrated ProjectIncludes supplementary material. Executive Summary and Presentation.Recent conflicts such as Operation Desert Shield/Storm and Operation Iraqi Freedom highlight the logistics difficulties the United States faces by relying on foreign access and infrastructure and large supply stockpiles ashore to support expeditionary operations. The Navy's transformational vision for the future, Sea Power 21, involves Seabasing as a way to address these difficulties by projecting and sustaining joint forces globally from the sea. This study analyzes logistics flow to, within and from a Sea Base to an objective, and the architectures and systems needed to rapidly deploy and sustain a brigade-size force. Utilizing the Joint Capabilities Integration and Development System (JCIDS), this study incorporates a systems engineering framework to examine current systems, programs of record and proposed systems out to the year 2025. Several capability gaps that hamper a brigade-size force from seizing the initiative anywhere in the world within a 10-day period point to a need for dedicated lift assets, such as high-speed surface ships or lighter-than-air ships, to facilitate the rapid formation of the Sea Base. Additionally, the study identifies the need for large-payload/high-speed or load-once/direct-to- objective connector capabilities to minimize the number of at-sea transfers required to employ such a force from the Sea Base in 10 hrs. With these gaps addressed, the Joint Expeditionary Brigade is supportable from the Sea Base.http://archive.org/details/seabasingndjoint109456918N

Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type 2 immune response to helminth parasites. However its role in the later effector phase of clearing chronic infection remains unclear. The helminth Heligmosomoides polygyrus establishes long-term infections in susceptible C57BL/6 mice, but is slowly expelled in BALB/c mice from day 14 onwards. We noted that IL-25R (Il17rb)-deficient BALB/c mice were unable to expel parasites despite type 2 immune activation comparable to the wild-type. We then established that in C57BL/6 mice, IL-25 adminstered late in infection (days 14-17) drove immunity. Moreover when IL-25 and IL-4 were delivered to Rag1-deficient mice, the combination resulted in near complete expulsion of the parasite, even following administration of an anti-CD90 antibody to deplete innate lymphoid cells (ILCs). Hence, effective anti-helminth immunity during chronic infection requires an innate effector cell population that is synergistically activated by the combination of IL-4Rα and IL-25R signaling

Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion

Gastro-intestinal helminth infections trigger the release of interleukin-33 (IL-33), which induces type-2 helper T cells (Th2 cells) at the site of infection to produce IL-13, thereby contributing to host resistance in a T cell receptor (TCR)-independent manner. Here, we show that, as a prerequisite for IL-33-induced IL-13 secretion, Th2 cells required the expression of the epidermal growth factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex between T1/ST2 (the IL-33R) and EGFR. This shared signaling complex allowed IL-33 to induce the EGFR-mediated activation of the MAP-kinase signaling pathway and consequently the expression of IL-13. Lack of EGFR expression on T cells abrogated IL-13 expression in infected tissues and impaired host resistance. EGFR expression on Th2 cells was TCR-signaling dependent, and therefore, our data reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher eukaryotes, making it an attractive target for antibacterials. The fluoroquinolones are examples of very successful gyrase-targeted drugs, but the rise in bacterial resistance to these agents means that we not only need to seek new compounds, but also new modes of inhibition of this enzyme. We review known gyrase-specific drugs and toxins and assess the prospects for developing new antibacterials targeted to this enzyme

ILC2s—Trailblazers in the Host Response Against Intestinal Helminths

Group 2 innate lymphoid cells (ILC2s) were first discovered in experimental studies of intestinal helminth infection—and much of our current knowledge of ILC2 activation and function is based on the use of these models. It is perhaps not surprising therefore that these cells have also been found to play a key role in mediating protection against these large multicellular parasites. ILC2s have been intensively studied over the last decade, and are known to respond quickly and robustly to the presence of helminths—both by increasing in number and producing type 2 cytokines. These mediators function to activate and repair epithelial barriers, to recruit other innate cells such as eosinophils, and to help activate T helper 2 cells. More recent investigations have focused on the mechanisms by which the host senses helminth parasites to activate ILC2s. Such studies have identified novel stromal cell types as being involved in this process—including intestinal tuft cells and enteric neurons, which respond to the presence of helminths and activate ILC2s by producing IL-25 and Neuromedin, respectively. In the current review, we will outline the latest insights into ILC2 activation and discuss the requirement for—or redundancy of—ILC2s in providing protective immunity against intestinal helminth parasites

Agricultural cropland extent and areas of South Asia derived using Landsat satellite 30-m time-series big-data using random forest machine learning algorithms on the Google Earth Engine cloud

The South Asia (India, Pakistan, Bangladesh, Nepal, Sri Lanka and Bhutan) has a staggering 900 million people (~43% of the population) who face food insecurity or severe food insecurity as per United Nations, Food and Agriculture Organization’s (FAO) the Food Insecurity Experience Scale (FIES). The existing coarse-resolution (≥250-m) cropland maps lack precision in geo-location of individual farms and have low map accuracies. This also results in uncertainties in cropland areas calculated from such products. Thereby, the overarching goal of this study was to develop a high spatial resolution (30-m or better) baseline cropland extent product of South Asia for the year 2015 using Landsat satellite time-series big-data and machine learning algorithms (MLAs) on the Google Earth Engine (GEE) cloud computing platform. To eliminate the impact of clouds, 10 time-composited Landsat bands (blue, green, red, NIR, SWIR1, SWIR2, Thermal, EVI, NDVI, NDWI) were derived for each of the three time-periods over 12 months (monsoon: Days of the Year (DOY) 151–300; winter: DOY 301–365 plus 1–60; and summer: DOY 61–150), taking the every 8-day data from Landsat-8 and 7 for the years 2013–2015, for a total of 30-bands plus global digital elevation model (GDEM) derived slope band. This 31-band mega-file big data-cube was composed for each of the five agro-ecological zones (AEZ’s) of South Asia and formed a baseline data for image classification and analysis. Knowledge-base for the Random Forest (RF) MLAs were developed using spatially well spread-out reference training data (N = 2179) in five AEZs. The classification was performed on GEE for each of the five AEZs using well-established knowledge-base and RF MLAs on the cloud. Map accuracies were measured using independent validation data (N = 1185). The survey showed that the South Asia cropland product had a producer’s accuracy of 89.9% (errors of omissions of 10.1%), user’s accuracy of 95.3% (errors of commission of 4.7%) and an overall accuracy of 88.7%. The National and sub-national (districts) areas computed from this cropland extent product explained 80-96% variability when compared with the National statistics of the South Asian Countries. The full-resolution imagery can be viewed at full-resolution, by zooming-in to any location in South Asia or the world, at www.croplands.org and the cropland products of South Asia downloaded from The Land Processes Distributed Active Archive Center (LP DAAC) of National Aeronautics and Space Administration (NASA) and the United States Geological Survey (USGS): https://lpdaac.usgs.gov/products/gfsad30saafgircev001/

Mapping cropland fallow areas in myanmar to scale up sustainable intensification of pulse crops in the farming system

Cropland fallows are the next best-bet for intensification and extensification, leading to increased food production and adding to the nutritional basket. The agronomical suitability of these lands can decide the extent of usage of these lands. Myanmar’s agricultural land (over 13.8 Mha) has the potential to expand by another 50% into additional fallow areas. These areas may be used to grow short-duration pulses, which are economically important and nutritionally rich, and constitute the diets of millions of people as well as provide an important source of livestock feed throughout Asia. Intensifying rice fallows will not only improve the productivity of the land but also increase the income of the smallholder farmers. The enhanced cultivation of pulses will help improve nutritional security in Myanmar and also help conserve natural resources and reduce environmental degradation. The objectives of this study was to use remote sensing methods to identify croplands in Myanmar and cropland fallow areas in two important agro-ecological regions, delta and coastal region and the dry zone. The study used moderate-resolution imaging spectroradiometer (MODIS) 250-m, 16-day normalized difference vegetation index (NDVI) maximum value composite (MVC), and land surface water index (LSWI) for one 1 year (1 June 2012–31 May 2013) along with seasonal field-plot level information and spectral matching techniques to derive croplands versus cropland fallows for each of the three seasons: the monsoon period between June and October; winter period between November and February; and summer period between March and May. The study showed that Myanmar had total net cropland area (TNCA) of 13.8 Mha. Cropland fallows during the monsoon season account for a meagre 2.4% of TNCA. However, in the winter season, 56.5% of TNCA (or 7.8 Mha) were classified as cropland fallows and during the summer season, 82.7% of TNCA (11.4 Mha) were cropland fallows. The producer’s accuracy of the cropland fallow class varied between 92 and 98% (errors of omission of 2 to 8%) and user’s accuracy varied between 82 and 92% (errors of commission of 8 to 18%) for winter and summer, respectively. Overall, the study estimated 19.2 Mha cropland fallows from the two major seasons (winter and summer). Out of this, 10.08 Mha has sufficient moisture (either from rainfall or stored soil water content) to grow short-season pulse crops. This potential with an estimated income of US$300 per hectare, if exploited sustainably, is estimated to bring an additional net income of about US$ 1.5 billion to Myanmar per year if at least half (5.04 Mha) of the total cropland fallows (10.08 Mha) is covered with short season pulses

Mapping cropland fallow areas in Myanmar to scale up sustainable intensification of pulse crops in the farming system

Cropland fallows are the next best-bet for intensification and extensification, leading to increased food production and adding to the nutritional basket. The agronomical suitability of these lands can decide the extent of usage of these lands. Myanmar’s agricultural land (over 13.8 Mha) has the potential to expand by another 50% into additional fallow areas. These areas may be used to grow short-duration pulses, which are economically important and nutritionally rich, and constitute the diets of millions of people as well as provide an important source of livestock feed throughout Asia. Intensifying rice fallows will not only improve the productivity of the land but also increase the income of the smallholder farmers. The enhanced cultivation of pulses will help improve nutritional security in Myanmar and also help conserve natural resources and reduce environmental degradation. The objectives of this study was to use remote sensing methods to identify croplands in Myanmar and cropland fallow areas in two important agro-ecological regions, delta and coastal region and the dry zone. The study used moderate-resolution imaging spectroradiometer (MODIS) 250-m, 16-day normalized difference vegetation index (NDVI) maximum value composite (MVC), and land surface water index (LSWI) for one 1 year (1 June 2012–31 May 2013) along with seasonal field-plot level information and spectral matching techniques to derive croplands versus cropland fallows for each of the three seasons: the monsoon period between June and October; winter period between November and February; and summer period between March and May. The study showed that Myanmar had total net cropland area (TNCA) of 13.8 Mha. Cropland fallows during the monsoon season account for a meagre 2.4% of TNCA. However, in the winter season, 56.5% of TNCA (or 7.8 Mha) were classified as cropland fallows and during the summer season, 82.7% of TNCA (11.4 Mha) were cropland fallows. The producer’s accuracy of the cropland fallow class varied between 92 and 98% (errors of omission of 2 to 8%) and user’s accuracy varied between 82 and 92% (errors of commission of 8 to 18%) for winter and summer, respectively. Overall, the study estimated 19.2 Mha cropland fallows from the two major seasons (winter and summer). Out of this, 10.08 Mha has sufficient moisture (either from rainfall or stored soil water content) to grow short-season pulse crops. This potential with an estimated income of US$300 per hectare, if exploited sustainably, is estimated to bring an additional net income of about US$ 1.5 billion to Myanmar per year if at least half (5.04 Mha) of the total cropland fallows (10.08 Mha) is covered with short season pulses